Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 11th Global Healthcare and Fitness Summit San Francisco, California, USA.

Day 2 :

Keynote Forum

K Zaman

International Centre for Diarrheal Disease Research, Bangladesh

Keynote: Methodology, results and lessons-learned from the phase I to IV clinical trials with all three FDA licensed Rotavirus vaccines in Bangladesh

Time : 9:40-10:20

Conference Series HealthCare 2017 International Conference Keynote Speaker K Zaman photo

K Zaman has been working as Senior Scientist and Epidemiologist at the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR, B), in the Infectious Diseases Division. For the last 35 years, he has gained extensive experience in the design, implementation, and analysis of data from clinical and community-based epidemiological/vaccine studies. His primary interests are to conduct researches on vaccines and infectious diseases. Currently, he is the Principal Investigator of several Flu, Tuberculosis, Oral polio, Hepatitis E, Japanese encephalitis, Pneumococcal and Rotavirus vaccine studies in ICDDR, B. He has received several awards and has more than 155 publications in international journals and had 120 conference presentations.


Safe and effective Rotavirus vaccines are needed to reduce the enormous public health burden associated with Rotavirus illness,
especially in developing countries. Prevention by vaccination is critical for effective control of Rotavirus infection since it cannot be prevented with improvements in water and sanitation. The International Centre for Diarrhoeal Disease Research,Bangladesh (ICDDR, B) has completed several Rotavirus vaccine (RV) trials which ranged from phase I to licensure and post marketing evaluation of the vaccines (phase IV). Three FDA (USA) licensed Rotavirus vaccines were tested and evaluated in these trails: Tetravalent rhesus Rotavirus vaccine (RRV-TV, Rota Shield, Wyeth Lederle), Pentavalent Rotavirus vaccine (PRV,RotaTeq®, Merck & Co.) and monovalent Rotavirusvaccine(Rotarix®,GlaxoSmithKline). The trials were conducted in urban and rural areas and the sample size ranged from few hundreds to several thousands. The safety, immunogenicity, efficacy and effectiveness of the vaccines were evaluated. RV did not interfere with the immunogenicity of oral polio vaccine and measles and rubella vaccine. The efficacy and effectiveness of the vaccines were 40-45%. Inclement weather, difficult transportation,and movement of study participants were some of the challenges identified. Bangladesh Government is actively thinking to introduce RV vaccine into EPI program and adequate cold chain facilities need to be established. Details f the methodology,results, lessons-learned and challenges for successful implementation of these trials will be presented.