Z Lamari
Nuclear Research Center of Draria | Algeria
Title: Analysis of Aristolochia longa medicinal plant from Algeria
Biography
Biography: Z Lamari
Abstract
Seven elements have been determined using neutron activation analysis technique usually quite for herbs analyses. The essential elements found in Aristolochia Longa in this work may be potentially correlated with their therapeutic effect. However there is a need to investigate the toxic composition of Bereztem. It is clear the people using this plant especially the cancer patients in association or not with another therapy for economic considerations and or hope of cure should pay attention because the aristolochic acid contains. This acid is Very dangerous. The aristolochic acids Nephropathy (NAA) called also Chinese plants Nephropathy NCP is a diseases identified for the women having followed a Chinese slimming diet in 1992 , and a new American study reveals that this Acid is more carcinogen than the tobacco. When The Aristolochic Acid extracted from a medicinal plant is traditionally used in China to cure some diseases, the arthritis and the other inflammations. Dr. Selda and his colleagues show the direct toxicity of the Aristolochic acid on the human gene TP53 (gene suppressor of cancer).
Methodology & Theoretical Orientation: The medicinal plant Aristilochia Longa is collected from Taourirt Aden Algerian village situated in Kabylia region Northern Algeria. The root was washed extensively in distillated water as to remove superficial dust. The dry and hard form of this part was ground in a steel mortar; the fine powder obtained was prepared for neutron Activation Analysis.
Findings: it is possible to separate the useful from the toxic fractions of plant, instead to banned the use of herbal remedy containing acid Aristolochic. Five elements were quantified in certified AIEA standards IAEA-V10 and IAEA-SL1 for checking the accuracy of our procedure. It was noteworthy the most of the values obtained from this work are in good agreement with the certified values. The Z-score values for all elements were |Z|<3, which means that the results obtained are acceptable. the elemental concentrations obtained from this work shows the usefulness of using INAA for the elemental determination, the La, K, Br, As are present at trace levels and the Cr, Sb was found at minor level and Na at the major level.
Recent Publications
- Cherif H.S, F. Said et al (2009) Identification et caracterisation de Quelques Composés chimiques chez Aristolochia Longa.nr.3- 4 : 71- 72.
- Jean-pierre Cosyns (2004) Aristolochic Acid-and ochratoxin A- DNA adducts: possible markers of Balkan endemic nephropathy and associated urotherial tumors Medicine and Biology 11,N°1 : 1- 4.
- Chung-Hsin Chen et al (2012) Aristolochic acid – associated Urotherial cancer in Taiwan PNAS /may 221 / 109 / n° 21 : 8241- 8246.
- Jian Qing Yu, Zhi Xiong Liao et al (2007) Composition , Antimicrobial activity and cytotoxicity of essential oils from Aristolochia mollissima : Environmental Toxicology and Pharmacology 23 : 162-167.
- Bachir et al. (2012) Aristolochia Longa aqueous extract triggers the mitochondrial pathway of apoptosis in BL41 Burkitt’s lymphoma cells : International Journal of Green Pharmacy : 45-49.