University of Siena | Italy
Title: Rationale for the use of megadoses of Vitamin C in the treatment of cancer
Biography: Domenico Mastrangelo
The selective anticancer properties of Vitamin C are known since at least four decades. However, only recently in vitro studies have shown that Vitamin C, in high enough concentrations, can efficiently and selectively kill a number of different human tumor cell lines, and these data have been confirmed in experimental animal tumor models.
The first human clinical trials, revealed that high doses of Vitamin C administered by intravenous injection, are not only very well tolerated, but substantially improve the quality of life of patients with clinically advanced cancer. However the clinical evidence of the effectiveness of Vitamin C in fighting off cancer, is still controversial.
The present chapter outlines the importance of Vitamin C for a number of physiologic functions, within the human body and shows that there is a solid rationale for its use in the routine treatment of cancer, either alone or in combination with conventional treatment.