United Arab Emirates University, UAE
Title: A common spice prevents liver cancer lesions: Bioinformatics and network analyse
Biography: Amr Amin
The multi-kinase inhibitor, sorafenib, remains for a decade now the first and only systemic therapy for the treatment of Hepatocellular Carcinoma (HCC). Thus, a novel approach against HCC is essential for a better therapeutic outcome. The aims of this study is to assess the chemo-preventive action of Saffron’s main biomolecule, crocin, against chemically-induced liver cancer in rats and to explore the mechanisms by which crocin employs its anti-tumor effects. We provide a network analysis of diff erentially expressed genes in tissues of animals pre-treated with crocin in comparison to induced-HCC animals’ tissues. To further support our results, we assessed the effects of crocin on HepG2 cells viability by treating them with various concentration of crocin; in addition, effects of crocin on cell cycle distribution of HepG2 cells were investigated. Network
analysis identifi ed NF-kB as a potential regulatory hub and therefore, a candidate therapeutic drug target.