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Yan Liu

Yan Liu

Korea University of Science and Technology, South Korea

Title: Acupuncture lowers blood pressure in mild hypertension patients: A randomized, controlled, assessor-blinded pilot trial


Biography: Yan Liu


Objectives: To preliminarily assess the effects of acupuncture on pre-hypertension and stage I hypertension and to provide data for further research. Design: A randomized, controlled, assessor-blinded study with an 8-week intervention period and a 4-week follow-up. Interventions: Participants were patients with systolic blood pressure (SBP) of 120–159 mm Hg or diastolic blood pressure (DBP) of 80–99 mm Hg. Thirty participants were allocated to acupuncture group or untreated control group at a 1:1 ratio. The acupuncture group received standard acupuncture twice weekly for 8 weeks and was followed-up for 4 weeks after treatment; the control group did not receive any type of anti-hypertensive treatment for 12 weeks. Main Outcome Measures: Primary outcome measure was SBP and DBP at post-treatment. The secondary outcomes were SBP and DBP at follow-up; Euro Quality of life (EQ-5D), heart rate variability (HRV), body-mass index (BMI) and blood lipid profile. Results: DBP (−5.7 mmHg; P=0.025), but not SBP (−6.0 mmHg; P=0.123), was significantly different between groups at post-treatment. Both DBP (−7.8 mmHg; P=0.004) and SBP (−8.6 mmHg; P=0.031) were significantly different at follow-up. Among the HRV indices, only high frequency power was significantly different between groups at weeks 4 and 8 (P=0.047 and P=0.030, respectively). There were no differences between groups in EQ-5D, BMI or lipid profile. Conclusion: The results of this study show that acupuncture might lower blood pressure in pre-hypertension and stage I hypertension and further RCT need 97 participants in each group. The effect of acupuncture on pre-hypertension and mild hypertension should be confirmed in larger studies.